(en) One of the highlights of the current recommendations of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH) for the management of arterial hypertension published in 20181 is the strong position in favor of a single-pill combination (SPC) comprising 2 antihypertensive drugs as first-line treatment in most hypertensive patients. The scope of this article is to summarize the background and evidence supporting this recommendation.[...]
Persu, A., Lopez-Sublet, M., Algharably, E. A. E.-H., & Kreutz, R. (2021). Starting Antihypertensive Drug Treatment With Combination Therapy: Controversies in Hypertension - Pro Side of the Argument. Hypertension, 77(3), 800-805. https://doi.org/10.1161/HYPERTENSIONAHA.120.12857 (Original work published 2021)