The anti-inflammatory effects of ketamine: State of the art
(2011) Acta Anaesthesiologica Belgica — Vol. 62, n° 1, p. 47-58 (2011)
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- Abstract
- Inflammation is a major component in keeping the body in homeostasis. However, an overwhelmed inflammatory response may be associated to a loss of this homeostatic status, which may lead to tissue injury or organ dysfunction. A huge number of drugs interacts with the inflammatory response in a positive, negative or "dual" manner. Among these drugs, ketamine seems to have a significant positive effect on the regulation of inflammation. This NMDA-receptor antagonist acts at different levels of inflammation, interacting with inflammatory cells recrutment, cytokins production, and inflammatory mediators regulation. The resultant effect of these interactions confers to ketamine a antiproinflammatory effect by limiting exacerbation of systemic inflammation without affecting local healing processes. This review makes a complete overview of the immunomodulatory properties of this complex anesthetic substance. © Acta Anæsthesiologica Belgica, 2011.
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Loix, S., De Kock, M., & Henin, P. (2011). The anti-inflammatory effects of ketamine: State of the art. Acta Anaesthesiologica Belgica, 62(1), 47-58. https://hdl.handle.net/2078.5/187480 (Original work published 2011)