The mechanisms of activation of the single chain cytokine receptors: Preformed and ligand-induced dimerization
(2014) Biopolymers and Cell — Vol. 30, n° 3, p. 184-189 (2014)
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- Despite intensive studies, the mechanisms of cytokine receptor activation are still not completely understood. Historically two models have been proposed: early studies suggested a mechanism involving ligand-induced dimerization of the receptors which results in the activation of downstream signaling pathways, whereas, in the absence of ligands, the receptors are thought to be in a monomeric inactive state; later studies uncovered evidence for the existence of many receptors as inactive preformed dimers, which upon ligand binding undergo conformational changes and/or relative rotation of the receptor molecules. Here we focus on the dimerization status of the single chain cytokine receptors, which are involved in the regulation of hematopoiesis. © Institute of Molecular Biology and Genetics, NAS of Ukraine, 2014.
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Gryshkova, V. S., Albu, R. I., & Constatinescu, S. N. (2014). The mechanisms of activation of the single chain cytokine receptors: Preformed and ligand-induced dimerization. Biopolymers and Cell, 30(3), 184-189. https://doi.org/10.7124/bc.000894 (Original work published 2014)