Immunomodulatory influence of bone marrow-derived mesenchymal stem cells on neuroinflammation in astrocyte cultures.

Schäfer, Sabrina;Calas, André-Guilhem;Vergouts, Maxime;Hermans, Emmanuel
(2012) Journal of Neuroimmunology — Vol. 249, n° (1-2), p. 40-48 (2012)

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Authors
  • Schäfer, SabrinaUCLouvain
    Author
  • Calas, André-GuilhemUCLouvain
    Author
  • Vergouts, MaximeUCLouvain
    Author
  • Hermans, EmmanuelUCLouvain
    Author
Abstract
The therapeutic benefits associated with mesenchymal stem cells (MSCs) largely result from their immunomodulatory and neurotrophic properties. In this study, we evaluated the effects of MSCs on astrocyte cultures exposed to lipopolysaccharide. In response to this inflammatory trigger, astrocytes showed an increased expression of pro-inflammatory genes (IL-1β, TNFα, IL-6), which was attenuated by pre-exposure to MSC conditioned medium. Furthermore, mediators released by MSCs increased cell proliferation and altered the regulation of intermediate filaments (GFAP, vimentin), pro-inflammatory enzymes (iNOS, COX-2) and receptors (TLR4, CD14, mGluR3, mGluR5). These data demonstrate that MSCs influence diverse cell types participating in the response to neuroinflammation.
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Schäfer, S., Calas, A.-G., Vergouts, M., & Hermans, E. (2012). Immunomodulatory influence of bone marrow-derived mesenchymal stem cells on neuroinflammation in astrocyte cultures. Journal of Neuroimmunology, 249((1-2)), 40-48. https://doi.org/10.1016/j.jneuroim.2012.04.018. (Original work published 2012)