Effects of intrathecal ketamine in the neonatal rat: evaluation of apoptosis and long-term functional outcome.

Walker, Suellen M; Westin, B David; Deumens, Ronald; Grafe, Marjorie; Yaksh, Tony L

doi:10.1097/ALN.0b013e3181dcd71c

Effects of intrathecal ketamine in the neonatal rat: evaluation of apoptosis and long-term functional outcome.

Walker, Suellen M

;

Westin, B David

;

Deumens, Ronald

;

Grafe, Marjorie

;

Yaksh, Tony L

(2010) Anesthesiology — Vol. 113, n° 1, p. 147-159 (2010)

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Authors

Walker, Suellen M
Author
Westin, B David
Author
Deumens, RonaldUCLouvain
Author
Grafe, Marjorie
Author
Yaksh, Tony L
Author

Abstract

Because acute pathology and long-term behavioral change occurred in the same dose range as antihyperalgesic effects, the therapeutic ratio of intrathecal ketamine is less than one in the neonatal rat. This measure facilitates comparison of the relative safety of spinally administered analgesic agents.

Affiliations

UCLouvainSSS/IONS/CEMO - Pôle Cellulaire et moléculaire

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Walker, S. M., Westin, B. D., Deumens, R., Grafe, M., & Yaksh, T. L. (2010). Effects of intrathecal ketamine in the neonatal rat: evaluation of apoptosis and long-term functional outcome. Anesthesiology, 113(1), 147-159. https://doi.org/10.1097/ALN.0b013e3181dcd71c (Original work published 2010)