3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors.
(2008) Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology — Vol. 18, n° 14, p. 4163-4167 (2008)
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- Abstract
- A series of novel 2-azetidinones (beta-lactams) bearing short alkenyl chains at C3 and N1 have been prepared and evaluated in vitro as inhibitors of human FAAH. Compound 9c (1-(4'-pentenoyl-3-(4'-pentenyl)-2-azetidinone)) featured an IC(50) value of 4.5muM and a good selectivity for FAAH versus MGL.
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Urbach, A., Muccioli, G., Stern, E., Lambert, D., & Marchand-Brynaert, J. (2008). 3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors. Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology, 18(14), 4163-4167. https://doi.org/10.1016/j.bmcl.2008.05.081 (Original work published 2008)