The intestinal nuclear receptor signature with epithelial localization patterns andexpression modulation in tumors.

Modica, Salvatore;Gofflot, Françoise;Murzilli, Stefania;D'Orazio, Andria;Moschetta, Antonio;et.al.
(2010) Gastroenterology — Vol. 138, n° 2, p. 636-648 (2010)

Files

Modicaetal.pdf
  • Restricted Access
  • Adobe PDF
  • 7.48 MB
Request a copy

Details

Authors
  • Modica, Salvatore
    Author
  • Gofflot, Françoiseorcid-logoUCLouvain
    Author
  • Murzilli, Stefania
    Author
  • D'Orazio, Andria
    Author
  • Moschetta, Antonio
    Author
Show more
Abstract
The WNT-adenomatous polyposis coli system controls cell fate in the intestinal epithelium, where compartment-specific genes tightly regulate proliferation, migration, and differentiation. Nuclear receptors are transcription factors functioning as sensors of hormones and nutrients that are known to contribute to colon cancer progression. Here we mapped the messenger RNA (mRNA) abundance and the epithelial localization of the entire nuclear receptor family in mouse and human intestine.
Affiliations

Citations

  • APA
  • Chicago
  • FWB

Modica, S., Gofflot, F., Murzilli, S., D’Orazio, A., Salvatore, L., Pellegrini, F., Nicolucci, A., Tognoni, G., Copetti, M., Valanzano, R., Veschi, S., Mariani-Costantini, R., Palasciano, G., Schoonjans, K., Auwerx, J., & Moschetta, A. (2010). The intestinal nuclear receptor signature with epithelial localization patterns andexpression modulation in tumors. Gastroenterology, 138(2), 636-648. https://doi.org/10.1053/j.gastro.2009.09.060 (Original work published 2010)