Survival of primordial follicles: tips and tricks
(2020) Principles and Practice of Fertility Preservation — ISBN: [9780511921896], accepted/in-press
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- Abstract
- According to the European Society of Human Reproduction and Embryology (ESHRE) Working Group on Oocyte Cryopreservation [1], between 2010 and 2014, cancer patients in Europe underwent similar numbers of ovarian tissue cryopreservation procedures (~4400) and oocyte cryopreservation procedures (~3800). This milestone in the field of ovarian tissue cryopreservation is responsible for a new surge of interest in primordial follicles and their requirements for survival and development, as they represent more than 90% of the follicle population to be cryopreserved. When patients cannot have their frozen-thawed ovarian tissue reimplanted due to the risk of transmission of malignant cells, these follicles can be isolated and grafted inside a bioengineered ovary (see Chapter 36) or grown in vitro (see Chapter 31). We will focus on the latter strategy, more specifically on the main elements that primordial follicles need to survive in vitro.
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Citations
Andrade Amorim, C., & Lucci, C. M. (2020). Survival of primordial follicles: tips and tricks. In Donnez J, Kim SS (ed.), Principles and Practice of Fertility Preservation. Cambridge University Press. https://hdl.handle.net/2078.5/93992