In this talk, I investigate one of Charles Sanders Peirce’s most insightful theses: his view on scepticism. Peirce’s approach to the subject is both brief and scattered. Although the considerations he developed in “Some Consequences of Four Incapacities” (EP 1: 281) and “The Fixation of Belief” (EP 1: 107) have been significantly analysed, the corresponding developments in some subsequent manuscripts are practically unknown (especially CP 1.344, CP 5.391 and CP 6.498). The purpose of this presentation is twofold: after presenting some of the most interesting arguments found in these manuscripts, I turn to an analysis of the application of Peirce’s anti-scepticism for moral epistemology.