Coexistence of BCL1/CCND1 and CMYC aberrations in blastoid mantle cell lymphoma: a rare finding associated with very poor outcome.

Michaux, Lucienne;Théate, Ivan;Wlodarska, Iwona;Stul, M.;Ferrant, Augustin;et.al.
(2004) Annals of hematology —

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Authors
  • Michaux, LucienneUCLouvain
    Author
  • Théate, IvanUCLouvain
    Author
  • Wlodarska, IwonaUCLouvain
    Author
  • Stul, M.
    Author
  • Scheiff, Jean-MarieUCLouvain
    Author
  • Deneys, VéroniqueUCLouvain
    Author
  • Hagemeijer, AnneUCLouvain
    Author
  • Ferrant, AugustinUCLouvain
    Author
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Abstract
A patient with mantle cell lymphoma (MCL) of the pleomorphic blastoid subtype is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient survived only 2 months. Cytogenetically, a t(11;19;14)(q13;q13;q32) was found. Fluorescent in situ hybridization (FISH) and molecular analyses demonstrated involvement of the BCL1/CCND1 locus in a three-way translocation. In addition, subclonal abnormalities of the region 8q24 manifested either as a t(8;22)(q24;q11)/CMYC rearrangement or trisomy 8 were identified. The pathogenetic impact of this very uncommon association of BCL1/CCND1 and CMYC rearrangements in MCL is discussed and the literature is reviewed.
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Michaux, L., Théate, I., Wlodarska, I., Stul, M., Scheiff, J.-M., Deneys, V., Hagemeijer, A., & Ferrant, A. (2004). Coexistence of BCL1/CCND1 and CMYC aberrations in blastoid mantle cell lymphoma: a rare finding associated with very poor outcome. Annals of hematology. https://doi.org/10.1007/s00277-004-0879-2