Nonsurgical cerebellar mutism (anarthria) in two children
(2003) Pediatric Neurology — Vol. 28, n° 1, p. 59-63 (2003)
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- Cerebellar mutism (anarthria) is a well-described complication of posterior fossa tumor resection. It is accompanied by a characteristic behavior including irritability and autistic features. This syndrome is typically reversible within days to months. Underlying pathophysiology is unknown. We describe two children who presented with a similar clinical finding after nonsurgical cerebellar involvement, hemolytic-uremic syndrome in one and cerebellitis in the other. Postmortem pathologic findings in the first patient indicated cerebellar ischemic necrosis. Single-photon emission computed tomography in the second patient revealed diffuse cerebellar hypoperfusion with no supratentorial abnormalities, refuting a phenomenon of diaschisis between cerebellar and frontal connections. These findings confirm that this clinical syndrome may occur in a nonsurgical, nontraumatic context. They are consistent with recent integrative hypotheses explaining cerebellar anarthria. (C) 2003 by Elsevier Science Inc. All rights reserved.
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Mewasingh, L., Kadhim, H., Christophe, C., Christiaens, F., & Dan, B. (2003). Nonsurgical cerebellar mutism (anarthria) in two children. Pediatric Neurology, 28(1), 59-63. https://doi.org/10.1016/S0887-8994(02)00503-1 (Original work published 2003)