Evaluation of lauroyl-gemcitabine-loaded hydrogel efficacy in glioblastoma rat models.
(2018) Nanomedicine (London, England) — (2018)
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- Authors
Bastiancich, Chiara 
- Abstract
- Anticancer drug-loaded hydrogels are a promising strategy for the local treatment of incurable brain tumors such as glioblastoma (GBM). Recently, we demonstrated the efficacy of lauroyl-gemcitabine lipid nanocapsule hydrogel (GemC-LNC) in a U-87 MG xenograft orthotopic mouse model. In this study, we developed a reliable and reproducible surgical procedure to resect orthotopic GBM tumors in rats. GemC-LNC hydrogel integrity was tested after brain administration in rats and its anti-tumor efficacy was tested on a 9L syngeneic orthotopic model. We demonstrated that LNC integrity is maintained at least for one week after local administration of GemC-LNC. GemC-LNC was able to delay the formation of recurrences in 9L tumor-bearing resected rats, demonstrating the efficacy of this nanomedicine hydrogel in this preclinical model. Our results confirm that GemC-LNC, a hydrogel uniquely formed by a nanocarrier and a cytotoxic drug, could be a promising and safe delivery tool for the local treatment of operable GBM tumors.
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Citations
Bastiancich, C., Lemaire, L., Bianco, J., Franconi, F., Danhier, F., Préat, V., Bastiat, G., & Lagarce, F. (2018). Evaluation of lauroyl-gemcitabine-loaded hydrogel efficacy in glioblastoma rat models. Nanomedicine (London, England). Published. https://doi.org/10.2217/nnm-2018-0057 (Original work published 2018)