Ex-vivo effects of intrapulmonary percussive ventilation on sputum rheological properties.
(2023) Respiratory Physiology & Neurobiology — Vol. 316, p. 104125 [1-7] (2023)
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- Intrapulmonary percussive ventilation (IPV) has been postulated to enhance mucociliary clearance by improving tracheobronchial sputum rheological properties. The IPV effects on linear (viscoelasticity) and non-linear (flowing) rheological properties of 40 sputum samples collected from 19 patients with muco-obstructive lung diseases were investigated ex-vivo. Each sputum sample was split into 4 aliquots. These aliquots were independently placed in a circuit connected on one side to an IPV device and on the other side to a lung model that simulated spontaneous adult breaths. IPV was superimposed on simulated breathing. Three aliquots were exposed to a different IPV setting, modifying either percussion frequency or amplitude (4 Hz-200 L/min, 10 Hz-200 L/min, 10 Hz-140 L/min). One aliquot was only exposed to breathing (IPV was switched off, control condition). Each aliquot underwent 5 min of the pre-fixed mechanical stimulation before being recollected to proceed to rheological analysis. Neither percussion frequencies nor amplitudes had a significant impact on any sputum rheological properties studied. These results need to be confirmed in vivo.
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Wiame, N., Robert de Saint-Vincent, M., Audag, N., Aubriot, A.-S., Penelle, M., Reychler, G., Patarin, J., & Poncin, W. (2023). Ex-vivo effects of intrapulmonary percussive ventilation on sputum rheological properties. Respiratory Physiology & Neurobiology, 316, 104125 [1-7]. https://doi.org/10.1016/j.resp.2023.104125 (Original work published 2023)