Development of a Regioselective N-Methylation of (Benz)imidazoles Providing the More Sterically Hindered Isomer.

Van Den Berge, Emilie;Robiette, Raphaël
(2013) The Journal of Organic Chemistry — Vol. 78, n° 23, p. 12220-12223 (2013)

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Abstract
An efficient and highly regioselective N-methylation of (NH)-(benz)imidazoles furnishing the sterically more hindered, less stable, and usually minor regioisomer has been developed. The methodology involves very mild reaction conditions and tolerates a wide range of functional groups.
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Van Den Berge, E., & Robiette, R. (2013). Development of a Regioselective N-Methylation of (Benz)imidazoles Providing the More Sterically Hindered Isomer. The Journal of Organic Chemistry, 78(23), 12220-12223. https://doi.org/10.1021/jo401978b (Original work published 2013)