Ultrasmall particle of iron oxide-RGD peptidomimetic conjugate: synthesis and characterisation.

Rerat, Vincent;Laurent, Sophie;Burtéa, Carmen;Driesschaert, Benoît;Marchand-Brynaert, Jacqueline;et.al.
(2010) Bioorganic & Medicinal Chemistry : the tetrahedron journal for research at the interface of chemistry and biology — Vol. 20, n° 6, p. 1861-1865 (2010)

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Authors
  • Rerat, VincentUCLouvain
    Author
  • Laurent, SophieUMons
    Author
  • Burtéa, CarmenUMons
    Author
  • Driesschaert, BenoîtUCLouvain
    Author
  • Pourcelle, VincentUCLouvain
    Author
  • Marchand-Brynaert, JacquelineUCLouvain
    Author
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Abstract
Ultrasmall particles of iron oxide (USPIOs) coated with 3,3'-bis(phosphonate)propionic acid were covalently coupled to a home-made Arg-Gly-Asp (RGD) peptidomimetic molecule via a short oligoethyleneglycol (OEG) spacer. The conjugation rate was measured by X-ray photoelectron spectroscopy (XPS). The particle size and magnetic characteristics were kept. Our novel conjugate targeted efficiently Jurkat cells (increase of 229% vs the control).
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Rerat, V., Laurent, S., Burtéa, C., Driesschaert, B., Pourcelle, V., Vander Elst, L., Muller, R. N., & Marchand-Brynaert, J. (2010). Ultrasmall particle of iron oxide-RGD peptidomimetic conjugate: synthesis and characterisation. Bioorganic & Medicinal Chemistry : the tetrahedron journal for research at the interface of chemistry and biology, 20(6), 1861-1865. https://doi.org/10.1016/j.bmcl.2010.01.150 (Original work published 2010)