Chemical analysis applied to the radiation sterilization of solid ketoprofen
(2006) Radiation Effects and Defects in Solids — Vol. 161, n° 1, p. 75-82 (2006)
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- The aim of this work is to investigate the feasibility of radiation sterilization of ketoprofen from a chemical point of view. Although irradiated ketoprofen has already been studied in the literature [Katusin-Razem et al., Radiat. Phys. Chem. 73 111-116 (2005)], new results, on the basis of electron spin resonance (ESR) measurements and the use of hyphenated techniques (GC-MS and LC-MS), are obtained. The ESR spectra of irradiated ketoprofen consists of four unresolved resonance peaks and the mean G-value of ketoprofen is found to be 4 +/- 0.9 nmoles/J, which is very small. HPLC-UV analyses indicate that no significant loss of ketoprofen is detected after irradiation. LC-MS-MS analyses show that the structures of the non-volatile final products are similar to ketoprofen. Benzaldehyde is detected in the irradiated samples after dynamic-extraction GC-MS. The analyses show that ketoprofen is radioresistant and therefore might be radiosterilized.
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Colak, S., Maquille, A., & Tilquin, B. (2006). Chemical analysis applied to the radiation sterilization of solid ketoprofen. Radiation Effects and Defects in Solids, 161(1), 75-82. https://doi.org/10.1080/10420150500213571 (Original work published 2006)