Assisted reproductive technology in young BRCA carriers with a pregnancy after breast cancer: An international cohort study.
(2025) European journal of cancer (Oxford, England : 1990) — Vol. 222, n° 2025, p. 115434 (2025)
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- Very limited data exist on assisted reproductive technology (ART) use in BRCA1/2 carriers conceiving after breast cancer. This study aimed to investigate the safety of ART to achieve a pregnancy after breast cancer in BRCA1/2 carriers. This is an international, hospital-based, retrospective cohort study including BRCA1/2 carriers with a pregnancy after prior breast cancer diagnosis at ≤ 40 years of age between 2000 and 2020. Outcomes were compared between young BRCA1/2 carriers who conceived using ART and those who conceived spontaneously. Among 543 BRCA1/2 carriers with a pregnancy after breast cancer, 436 conceived spontaneously and 107 using ART. Of 107 pregnancies achieved with ART, 45 (42.1 %) were obtained using oocytes/embryo cryopreserved at diagnosis, 33 (30.8 %) after controlled ovarian stimulation for in-vitro-fertilization/intracytoplasmic sperm injection or ovulation induction for intrauterine insemination or planned intercourse after anticancer treatments, 21 (19.6 %) after oocyte donation, while for 8 (7.5 %) patients type of ART was missing. Compared to patients in the no-ART group, those in the ART group were older at the time of conception, had more frequently hormone receptor-positive breast cancer and a longer median time from cancer diagnosis to conception. At a median follow-up of 5.2 years after conception, no apparent detrimental effect of ART on disease-free survival was observed (adjusted HR=0.72, 95 % CI 0.39-1.34). In young BRCA1/2 carriers with a pregnancy after breast cancer, ART use did not appear to be associated with increased risk of DFS events.
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Magaton, I. M., Blondeaux, E., Hamy, A.-S., Linn, S., Bernstein-Molho, R., Peccatori, F. A., Ferrari, A., Carrasco, E., Paluch-Shimon, S., Agostinetto, E., Venturelli, M., Luis, I. M. V., Rodriguez-Wallberg, K. A., Kim, H. J., Sorouri, K., Renaud, T., Moore, H. C. F., Cui, W., Bajpa, J., et al. (2025). Assisted reproductive technology in young BRCA carriers with a pregnancy after breast cancer: An international cohort study. European journal of cancer (Oxford, England : 1990), 222(2025), 115434. https://doi.org/10.1016/j.ejca.2025.115434 (Original work published 2025)