When the liver is in poor condition, so is the heart : cardiac remodelling and endothelial dysfunction in MASH mouse models
(2025)
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- Metabolic dysfunction-associated steatohepatitis (MASH) is the progressive form of fatty liver disease and a recognized cardiovascular risk factor (CVD). However, the mechanisms linking hepatic pathology to CVD remain poorly understood. Adverse cardiac and vascular alterations accompanying steatohepatitis were characterized in two MASH mouse models: Foz mice on a high fat diet and C57BL/6JRj fed a western diet with fructose Both models exhibited cardiac fibrosis and dysregulation of genes involved in pathological remodelling, as well as impaired •NO-dependent vasorelaxation without atherosclerotic lesions. Our findings reveal that MASH is consistently associated with adverse structural but not functional alterations in the heart, with ADMA emerging as a key liver-derived mediator of endothelial dysfunction.
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Bott, S. (2025). When the liver is in poor condition, so is the heart : cardiac remodelling and endothelial dysfunction in MASH mouse models. https://hdl.handle.net/2078.5/256268