Early monitoring of external radiation therapy by [(18)F]-fluoromethylcholine positron emission tomography and 3-T proton magnetic resonance spectroscopy : an experimental study in a rodent rhabdomyosarcoma model

Rommel, Denis;Abarca-Quinones, Jorge;Bol, Anne;Peeters, Frank;Duprez, Thierry;et.al.
(2010) Nuclear Medicine and Biology — Vol. 37, n° 5, p. 645-653 (2010)

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Authors
  • Rommel, DenisUCLouvain
    Author
  • Abarca-Quinones, JorgeUCLouvain
    Author
  • Bol, AnneUCLouvain
    Author
  • Peeters, FrankUCLouvain
    Author
  • Lhommel, Renaudorcid-logoUCLouvain
    Author
  • Lonneux, MaxUCLouvain
    Author
  • Labar, DanielUCLouvain
    Author
  • Grégoire, VincentUCLouvain
    Author
  • Duprez, ThierryUCLouvain
    Author
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Abstract
PURPOSE: To assess early radiation therapy (RT)-induced variations in total choline (tCho) concentration measured by proton magnetic resonance spectroscopy (H-MRS) and in (18)F-labelled fluoromethylcholine (FCH) uptake measured by PET in a rodent tumour model. METHODS: Nine rats bearing syngenic rhabdomyosarcoma grafts in both thighs were irradiated (13 Gy, one fraction). H-MRS data and FCH-PET were acquired in the same imaging session prior to and 3, 9 and 16 days after external RT. Total choline concentration was expressed in arbitrary units as the area under the curve of the 3.2-ppm peak on H-MR spectra. FCH uptake was expressed as maximum standardized uptake value (SUV(max)) and as the % of injected dose per gram (%ID/g) after precise tumour delineation on hybrid PET-MR images. Pre- and post-RT data were compared using the Student's paired t test, and results were expressed as mean+/-S.D. RESULTS: Seventeen tumours were available for analysis. A mean drop in choline concentration of 45% was observed 3 days after irradiation (P<.001), whereas a concomitant mean increase in SUV(max) of 41% was observed (P=.006). Choline concentration reincreased on later time points. CONCLUSIONS: Opposite trend between increased FCH uptake and decreased tCho peak was observed at 3 days. Later (9 and 16 days), uptake remained stable and tCho peak reincreased.
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Rommel, D., Abarca-Quinones, J., Bol, A., Peeters, F., Lhommel, R., Lonneux, M., Labar, D., Grégoire, V., & Duprez, T. (2010). Early monitoring of external radiation therapy by [(18)F]-fluoromethylcholine positron emission tomography and 3-T proton magnetic resonance spectroscopy : an experimental study in a rodent rhabdomyosarcoma model. Nuclear Medicine and Biology, 37(5), 645-653. https://doi.org/10.1016/j.nucmedbio.2010.03.005 (Original work published 2010)