Monitoring and tentative diagnosis of herpetic encephalitis by protein analysis of cerebrospinal fluid. Particular relevance of the assays of ferritin and S-100.
(1985) Journal of the Neurological Sciences — Vol. 67, n° 3, p. 359-369 (1985)
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- Abstract
- The cerebrospinal fluid (CSF) of 9 patients with herpetic encephalitis was analyzed by particle counting immunoassay of ferritin, S-100, immunoglobulins, anti-herpes antibodies and immune complexes and by electrophoresis for the detection of oligoclonal bands. The main conclusions are: first, the simultaneous increase of both ferritin and S-100 in the presence of symptoms of encephalitis suggests strongly the infection is herpetic; second, high and increasing levels of S-100, probably related to the extent of the necrotic process, indicate a poor prognosis. In addition, 8-14 days after onset, locally produced anti-herpes antibodies were detectable, the IgG index increased and oligoclonal bands became visible.
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Citations
Sindic, C., Kevers, L., Chalon, M. P., Laterre, E.-C., & Masson, P. (1985). Monitoring and tentative diagnosis of herpetic encephalitis by protein analysis of cerebrospinal fluid. Particular relevance of the assays of ferritin and S-100. Journal of the Neurological Sciences, 67(3), 359-369. https://doi.org/10.1016/0022-510X(85)90161-3 (Original work published 1985)