Lipid domains in érythrocytes : mapping, biophysical properties and contribution to calcium exchanges
(2019)
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- Authors
- Supervisors
- Tyteca, Donatienne
- Abstract
- Erythrocytes present a remarkable ability to deform. This deformability depends on several intrinsic erythrocyte features as well as on a tight regulation of the surface calcium exchanges. However, the importance of membrane lateral heterogeneity in lipid domains in the deformability process was still to be demonstrated. In this work, we investigated the mapping of lipid domains at the surface of resting state erythrocytes and characterized their biophysical properties. We then simulated the erythrocyte deformation or stimulated the calcium exchanges at the erythrocyte surface to evaluate the consequences of those stimulations on lipid domains. Our results suggest that several lipid domains with specific biophysical properties coexist at the plasma membrane of erythrocytes. Those domains are differentially modulated during erythrocyte deformation and some of them could be involved in calcium exchange regulation.
- Affiliations
Citations
Conrard, L. (2019). Lipid domains in érythrocytes : mapping, biophysical properties and contribution to calcium exchanges. https://hdl.handle.net/2078.5/125298