Two tyrosinase nonapeptides recognized on HLA‐A2 melanomas by autologous cytolytic T lymphocytes

Wölfel, Thomas;Van Pel, Aline;Brichard, Vincent;Schneider, Jörg;Boon-Falleur, Thierry;et.al.
(1994) European Journal of Immunology — Vol. 24, n° 3, p. 759-764 (1994)

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Authors
  • Wölfel, Thomas
    Author
  • Van Pel, AlineUCLouvain
    Author
  • Brichard, VincentUCLouvain
    Author
  • Schneider, Jörg
    Author
  • Boon-Falleur, ThierryUCLouvain
    Author
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Abstract
A number of cytolytic T lymphocyte (CTL) clones derived from several melanoma patients have been found to recognize a majority of melanomas from HLA-A2 patients. We have reported previously that two such CTL clones recognize a product of the tyrosinase gene that is presented by HLA-A2. Here we show that one of these CTL clones recognizes a peptide encoded by the first nine amino acids of the putative signal sequence of tyrosinase. The other CTL clone recognizes a different tyrosinase peptide corresponding to amino acids 368-376. Both peptides contain consensus motifs of HLA-A2 binding peptides.
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Wölfel, T., Van Pel, A., Brichard, V., Schneider, J., Seliger, B., zum Büschenfelde, K.-H. M., & Boon-Falleur, T. (1994). Two tyrosinase nonapeptides recognized on HLA‐A2 melanomas by autologous cytolytic T lymphocytes. European Journal of Immunology, 24(3), 759-764. https://doi.org/10.1002/eji.1830240340 (Original work published 1994)