Microenvironment-mediated lipid metabolism reprogramming upon anti-EGFR therapy resistance in head and neck squamous cell carcinoma
(2023)
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- Abstract
- Clinical response to anti-EGFR (cetuximab) therapy in patients with recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) is strongly limited by the occurrence of acquired resistance. While no genetic alteration is clearly associated with cetuximab resistance, tumor microenvironment actively contributes to disease progression and clinical relapse in HNSCC. By using multiple in vitro and in vivo experimental models, we characterized cetuximab-resistant HNSCC to rely on increased fatty acid uptake and oxidation in a PPAR-dependent manner. We identified some potential therapeutic avenues to target these cells and overcome resistance to cetuximab. We documented that cancer-associated fibroblasts exert a protective role against cetuximab in HNSCC cells through a lipid-based metabolic communication.
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Citations
Van den bossche, V. (2023). Microenvironment-mediated lipid metabolism reprogramming upon anti-EGFR therapy resistance in head and neck squamous cell carcinoma. https://hdl.handle.net/2078.5/27502