CD23 expression in aged rats.
(1992) International Archives of Allergy and Immunology — Vol. 97, n° 4, p. 330-336 (1992)
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- Abstract
- CD23 is considered as an activation marker. Its expression on lymphocytes was studied during aging by using 1- to 142-week-old rats. Before analysis, all animals were injected with monoclonal IgE, in order to detect their full expression of CD23 molecules on their lymphocyte surface membranes. In elderly rats, a decrease was observed in the percentages of CD23+ lymphocytes from mesenteric lymph nodes, spleen, Peyer's patches and peripheral blood. In addition, these lymphocytes expressed significantly fewer CD23 molecules per cell. Almost all CD23+ cells belonged to the B lineage and were bearing both IgM and IgD on their membranes. It is suggested that a decrease in the number of both IgM+IgD+CD23+ lymphocytes and CD23 molecules per cell may contribute to immune deficiency in the elderly.
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Chavez, V., Parreira Soares, M., & Bazin, H. (1992). CD23 expression in aged rats. International Archives of Allergy and Immunology, 97(4), 330-336. https://doi.org/10.1159/000236141 (Original work published 1992)