Isolation and Characterization of a Mage Gene Family in the Xp21.3 Region
(1995) National Academy of Sciences. Proceedings — Vol. 92, n° 11, p. 4987-4991 (1995)
Files
pdfdocument.pdf
Restricted Access - Adobe PDF
- 1.04 MB
Details
- Authors
- Abstract
- A human gene with strong homology to the MAGE gene family located in XqZ7-qter has been isolated by using exon-trapping of cosmids in the Xp21.3 region. We have mapped and sequenced cDNA and genomic clones corresponding to this gene, MAGE-Xp, and shown that the last exon contains the open reading frame and is present in a minimum of five copies in a 30-kb interval, MAGE-Xp, is expressed only in testis and, unlike the Xq27-qter MAGE genes, it is not expressed in any of 12 different tumor tissues tested. However, the gene and predicted protein structure are conserved, suggesting a similar function, MAGE-Xp is located in the 160-kb critical interval defined for the locus involved in sex determination within Xp21 and is 50 kb distal to the DAX-1 gene, which is responsible for X-chromosome-linked adrenal hypoplasia congenita.
- Affiliations
Citations
Muscatelli, F., Walker, AP., De Plaen, E., Stafford, AN., & Monaco, AP. (1995). Isolation and Characterization of a Mage Gene Family in the Xp21.3 Region. National Academy of Sciences. Proceedings, 92(11), 4987-4991. https://doi.org/10.1073/pnas.92.11.4987 (Original work published 1995)