Chitosan-coated electrospun nanofibers with antibacterial activity

Croisier, Florence;Sibret, Pierre;Dupont, Christine;Genet, Michel;Jérôme, Christine;et.al.
(2015) Journal of Materials Chemistry B — Vol. 3, p. 3508-3517 (2015)

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Authors
  • Croisier, Florence
    Author
  • Sibret, Pierre
    Author
  • Dupont, ChristineUCLouvain
    Author
  • Genet, MichelUCLouvain
    Author
  • Jérôme, Christine
    Author
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Abstract
Charged nanofibers were prepared by electrospinning (ESP) poly(e-caprolactone) with a copolymer bearing carboxylic acid functions. The presence of these functions allowed exposing some negative charges on the fiber surface, by dipping the fibers in a phosphate buffer. A layer of chitosan, a polycation in acidic medium, was then deposited on the nanofiber surface, thanks to electrostatic attraction. Fibers were characterized at each step of the process and the influence of the copolymer architecture on chitosan deposition was discussed. The antibacterial activity of the resulting fibers was finally assessed.
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Croisier, F., Sibret, P., Dupont, C., Genet, M., Detrembleur, C., & Jérôme, C. (2015). Chitosan-coated electrospun nanofibers with antibacterial activity. Journal of Materials Chemistry B, 3, 3508-3517. https://doi.org/10.1039/c5tb00158g (Original work published 2015)