Dual infection with polyomavirus BK and acyclovir-resistant herpes simplex virus successfully treated with cidofovir in a bone marrow transplant recipient
(2007) Transplant Infectious Disease (Print) — Vol. 9, n° 2, p. 126-131 (2007)
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- Abstract
- A hematopoietic stem cell transplant recipient developed a mucosal herpes simplex virus-1 (HSV-1) infection while under acyclovir (ACV) treatment (HSV was later shown to be resistant to ACV). Concomitantly, the patient presented a hemorrhagic cystitis (HC) due to polyomavirus BK, for which intravenous cidofovir (CDV) was prescribed. The patient benefited from the broad-spectrum anti-DNA virus activity of CDV, and not only the HC resolved without signs of nephrotoxicity but also the HSV-1 lesions disappeared. This is the first report describing the effect of CDV on 2 simultaneous and unrelated DNA viral infections in an immunosuppressed transplant recipient. In addition, we describe here that this HSV-1 isolate possesses a unique phenotype and genotype.
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Andrei, G., Goubau, P., Fiten, P., van Landuyt, H., Gordts, B., Selleslag, D., De Clercq, E., Opdenakker, G., & Snoeck, R. (2007). Dual infection with polyomavirus BK and acyclovir-resistant herpes simplex virus successfully treated with cidofovir in a bone marrow transplant recipient. Transplant Infectious Disease (Print), 9(2), 126-131. https://doi.org/10.1111/j.1399-3062.2006.00186.x (Original work published 2007)