Does haemophilia slow down the development of liver fibrosis?

(en) Dear Editor, Haemophilia is an X‐linked recessive bleeding disorder, resulting from deficient or dysfunctional coagulation factor VIII (haemophilia A) or IX (haemophilia B). Depending on the severity of their factor deficiency, patients present with a range of bleeding diathesis from traumatic injury or surgically induced bleeding to spontaneous haemorrhage in the soft tissues, joints or muscles. Before the 1960s, the prognosis of severe haemophilia A patients was just 11 years or less,1 then the introduction of fresh‐frozen plasma, cryoprecipitate, and finally blood‐pooled clotting factor concentrates considerably improved the survival and quality of life of patients with haemophilia or with other bleeding disorders.2 However, the epidemic of HCV and human immunodeficiency virus (HIV) then erupted with severe consequences. Until the 1989 discovery of HCV,3 almost all haemophilia patients treated with clotting factor products were infected with HCV.4 The clinical presentation of HCV is characterized by chronic liver disease that can progress to fibrosis with development of (de)compensated cirrhosis and hepatocellular carcinoma. [...]

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van Dievoet, M.-A., Leclercq, I., Hermans, C., Lambert, C., Horsmans, Y., Jacquemin, M., & Eeckhoudt, S. (2019). Does haemophilia slow down the development of liver fibrosis? Haemophilia (Print), 25(1), e32-e35. https://doi.org/10.1111/hae.13630 (Original work published 2019)