Demonstration of antigenic differences between strains of poliovirus type 1 by agar diffusion precipitation reaction.

Savinskaya, S S;Shekoyan, L A;Shirman, G A;Maiter, Dominique;et.al.
(1979) Acta Virologica : international journal — Vol. 23, n° 3, p. 183-188 (1979)

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  • Savinskaya, S S
    Author
  • Shekoyan, L A
    Author
  • Shirman, G A
    Author
  • Author
  • et. al.
Abstract
Antigenic differences between type 1 poliovirus strains circulating in nature were investigated by agar diffusion precipitation reaction. Three strain-specific sera were absorbed with antigens prepared from 8 strains (Sabin's vaccine strain LSc2ab and 7 strains isolated from poliomyelitis patients or healthy persons). The results suggested the presence of at least 5 antigenic determinants in the poliovirus type 1 strains studied. Three determinants in different combinations were found in 7 strains and 2 determinants were found in 1 strain. It is assumed that antigenic differences among poliovirus strains may be due to different combinations of several antigenic determinants.
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Savinskaya, S. S., Shekoyan, L. A., Shirman, G. A., Maiter, D., & et al. (1979). Demonstration of antigenic differences between strains of poliovirus type 1 by agar diffusion precipitation reaction. Acta Virologica : international journal, 23(3), 183-188. https://hdl.handle.net/2078.5/52431 (Original work published 1979)