(en) Aortic stenosis (AS) is a complex disease process involving fibrosis and calcification of the aortic valve leaflets. As there is no known effective medical therapy, the identification of modifiable risk factors for progression is a key objective. Epidemiological and pathophysiological evidence suggests a role of phosphate in the pathogenesis of cardiac valve calcification. We aimed to investigate the relationship between serum phosphate levels and the progression of AS. [...]
Candellier, A., Diouf, M., Bohbot, Y., Bennis, Y., Pasquet, A., Goffin, E., Hénaut, L., Choukroun, G., Vanoverschelde, J.-L., & Tribouilloy, C. (2024). Association Between Serum Phosphate Levels and Progression of Aortic Stenosis. JACC. Advances, 3(8), 101096 [1-3]. https://doi.org/10.1016/j.jacadv.2024.101096 (Original work published 2024)