Regulation and function of the thyroid hormone nuclear receptor TRα1 in cancer stem cell biology of colon cancer
(2022) Oncology Research Center Day - VUB/UZ Brussels — Location: Brussels (22.December.2022)
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- Abstract
- The thyroid hormone T3 and its nuclear receptor TRα1 control gut development and homeostasis via an action on the intestinal crypt stem cells (SC). The translational potential of the studies in mouse models has been proved in human colorectal cancer (CRC) patients as the increased TRα1 expression in CRC correlates with the activity of the Wnt pathway and with an increased “stem” potential. However, the molecular bases responsible for TRα1 expression regulation and the impact of T3 and TRα1 on cancer SC (CSC) biology were unknown. During this thesis, we aimed to: (1) Analyse the mechanisms that control THRA gene expression in colon cancer and CSCs. (2) Study TRα1 in CSCs, including their maintenance, differentiation, and implication on drug resistance.
- Affiliations
Vrije Universiteit Brussels
Citations
Giolito, M. V. (2022). Regulation and function of the thyroid hormone nuclear receptor TRα1 in cancer stem cell biology of colon cancer. Oncology Research Center Day - VUB/UZ Brussels, Brussels. https://hdl.handle.net/2078.5/267774