Glucose controls glucagon secretion with minor changes in alpha cell [Ca2+]c whereas sulfonylureas control glucagon secretion by increasing alpha cell [Ca2+]c and via somatostatin

Singh, Bilal;Khattab, Firas;Gilon, Patrick
(2019) 55th EASD Annual Meeting of the European Association for the Study of Diabetes — Location: (Spain) Barcelona (16.September.2019)

Files

2019_Singh_EASD_Abstract_517.pdf
  • Open Access
  • Adobe PDF
  • 2.16 MB
Download

Details

Authors
Abstract
BACKGROUND AND AIMS: The mechanisms by which glucose (G) and KATP channels control glucagon release are poorly understood. A rise in [Ca2+]c is considered as a signal triggering glucagon secretion. However, the effects of glucose and KATP channels on α-cell [Ca2+]c are hotly debated. In the present study, we tested the effects of glucose and KATP channel blockers (sulfonylureas) on α-cell [Ca2+]c using mice expressing the Ca2+indicator, GCAMP6f, specifically in α-cells, and we studied the correlation between α-cell [Ca2+]c and glucagon secretion. We also investigated the paracrine influence of somatostatin (SST) using Sst-/- mice. [...]
Affiliations

Citations

  • APA
  • Chicago
  • FWB

Singh, B., Khattab, F., & Gilon, P. (2019). Glucose controls glucagon secretion with minor changes in alpha cell [Ca2+]c whereas sulfonylureas control glucagon secretion by increasing alpha cell [Ca2+]c and via somatostatin. Diabetologia : clinical and experimental diabetes and metabolism, 62(Suppl 1), S252. https://hdl.handle.net/2078.5/119057 (Original work published 2019)