Heavy metal screening is currently very popular, especially on the web, and has become a “must do” for an increasing number of patients. The relative availability of inductively coupled plasma mass spectrometry equipments capable of measuring multiple elements at once has boosted the diffusion of these practices. In most cases, the list of elements measured in these screens reflects the analytical capacity of the lab more than sound toxicological considerations. These “urine mobilization tests”, “post-chelator challenges”, “provocative chelations”, “chelation challenges”, or “challenge tests” (hereafter called “provocative chelation test” [PCT]) represent an appreciable business. The screen almost systematically reveals “heavy metal poisoning”, and “detox cures” are generally recommended.[...]
Hoet, P., Haufroid, V., & Lison, D. (2020). Heavy metal chelation tests: the misleading and hazardous promise. Archives of toxicology, 94(8), 2893-2896. https://doi.org/10.1007/s00204-020-02847-7 (Original work published 2020)