Heterocyclizations of 3-trifluoroacetyl Substituted Lactams With Cyclic 1,3-bis-nucleophiles
(1995) Royal Society of Chemistry. Journal: Perkin Transactions 1 — n° 22, p. 2907-2912 (1995)
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- Abstract
- Pyrrolidinone 2, pyrimido[1,2-a]benzimidazoles 3a-c and 1,2,4-triazolo[4,3-a]pyrimidine 4 are prepared by condensation of 3-trifluoroacetyl substituted lactams 1a-c with cyclic 1,3-bis-nucleophiles. The nature of the nucleophile determines whether the reaction occurs with or without lactam ring opening.
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Citations
Bouillon, JP., Declercq, J.-P., Janousek, Z., Viehe, HG., & Tinant, B. (1995). Heterocyclizations of 3-trifluoroacetyl Substituted Lactams With Cyclic 1,3-bis-nucleophiles. Royal Society of Chemistry. Journal: Perkin Transactions 1, 22, 2907-2912. https://doi.org/10.1039/p19950002907 (Original work published 1995)