The boosting of didanosine by allopurinol permits a halving of the didanosine dosage
(2002) AIDS — Vol. 16, n° 16, p. 2221-2223 (2002)
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- Abstract
- The pharmacokinetic boosting of didanosine by allopurinol was studied in four HIV-1-positive patients taking didanosine, hydroxyurea and chloroquine, in whom the didanosine dosage was halved and allopurinol was added at 300 mg/day. Didanosine plasma levels and HIV-1-RNA levels remained unchanged after 4 and 17-20 months, respectively. Halving the didanosine dosage with allopurinol reduces treatment costs, and may lend itself to once-daily combination therapies, which are of particular interest for HIV therapy in resource-poor countries.
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Boelaert, J., Dom, G., Huitema, A., Beijnen, J., & Lange, J. (2002). The boosting of didanosine by allopurinol permits a halving of the didanosine dosage. AIDS, 16(16), 2221-2223. https://doi.org/10.1097/00002030-200211080-00016 (Original work published 2002)