Coombs-positive Autoimmune Hemolytic-anemia Complicating Ulcerative-colitis - a Case-report
(1991) Acta Gastro-Enterologica Belgica (Multilingual Edition) — Vol. 54, n° 1, p. 34-37 (1991)
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- Abstract
- We report the case of a 41-year-old woman with a 5-year history of left-sided ulcerative colitis easily controlled by sulfasalazine. She was admitted because of severe anemia, in the absence of any exacerbation of the colitis. A Coombs-positive (IgG type) hemolytic anemia was diagnosed and high-dose corticosteroid therapy was started, which proved to be unsuccessful. A splenectomy was then performed but the hemolytic anemia failed to subside. The patient was subsequently treated with a corticosteroid-azathioprine association with a sustained favourable effect on the anemia. The prevalence and pathophysiology of hemolytic anemia in ulcerative colitis is reviewed and a specific therapeutic approach is proposed.
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Martinez, P., Lambert, M., & Vanheuverzwyn, R. (1991). Coombs-positive Autoimmune Hemolytic-anemia Complicating Ulcerative-colitis - a Case-report. Acta Gastro-Enterologica Belgica (Multilingual Edition), 54(1), 34-37. https://hdl.handle.net/2078.5/137750 (Original work published 1991)