Fertility Restoration Options for Prepubertal Boys Undergoing Gonadotoxic Treatment

Wyns, Christine;Poels, Jonathan;Kanbar, Marc
(2026) Non-Obstructive Azoospermia — ISBN: [9783031994302], p. 185-201, published

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Abstract
Children undergoing treatment for cancer or certain benign diseases may receive gonadotoxic therapies that can lead to permanent oligo- or azoospermia during adulthood. As pre-pubertal boys do not produce sperm, banking of immature testicular tissue (ITT) containing spermatogonial stem cells (SSCs) is the only fertility preservation (FP) option available to date, although still considered experimental. Potential fertility restoration options using cryopreserved ITT include autografting, transplantation of isolated SSCs, and in vitro maturation (IVM). In this chapter, we summarize the state of the art of these techniques and clinical perspectives.
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Wyns, C., Poels, J., & Kanbar, M. (2026). Fertility Restoration Options for Prepubertal Boys Undergoing Gonadotoxic Treatment. In Zohdy, W., Gül, M., Shah, R., Agarwal, A. (eds) (ed.), Non-Obstructive Azoospermia (p. p. 185-201). Springer. https://doi.org/10.1007/978-3-031-99431-9_9