Innate lymphoid cells regulate intestinal epithelial cell glycosylation
(2014) Science — Vol. 345, n° 6202 (2014)
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- Fucosylation of intestinal epithelial cells, catalyzed by fucosyltransferase 2 (Fut2), is a major glycosylation mechanism of host-microbiota symbiosis. Commensal bacteria induce epithelial fucosylation, and epithelial fucose is used as a dietary carbohydrate by many of these bacteria. However, the molecular and cellular mechanisms that regulate the induction of epithelial fucosylation are unknown. Here, we show that type 3 innate lymphoid cells (ILC3) induced intestinal epithelial Fut2 expression and fucosylation in mice. This induction required the cytokines interleukin-22 and lymphotoxin in a commensal bacteria-dependent and -independent manner, respectively. Disruption of intestinal fucosylation led to increased susceptibility to infection by Salmonella typhimurium. Our data reveal a role for ILC3 in shaping the gut microenvironment through the regulation of epithelial glycosylation.
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Goto, Y., Kiyono, H., Benno, Y., Umesaki, Y., Sasakawa, C., Renauld, J.-C., Becher, B., Kulig, P., Domino, S. E., Akira, S., Uematsu, S., Imaoka, A., Setoyama, H., Matsuki, T., Sakamoto, M., Kamioka, M., Takeyama, N., Lamichhane, A., Ivanov, I. I., et al. (2014). Innate lymphoid cells regulate intestinal epithelial cell glycosylation. Science, 345(6202). https://doi.org/10.1126/science.1254009 (Original work published 2014)