Endometriosis: from iron and macrophages to exosomes. Is the sky clearing?
(2024) Human reproduction open — Vol. 2024, n° 3, p. hoae034 [1-5] (2024)
Files
hoae034.pdf
Open Access - Adobe PDF
- 847.59 KB
Details
- Authors
Donnez, Jacques 
- Abstract
- Determining the pathogenesis of endometriosis remains a challenge for gynecologists, reproduction specialists, endocrinologists, and researchers alike. Multifactorial causes have been reported, including ectopic endometrial tissue, altered immunity, unbalanced cell proliferation and apoptosis, oxidative stress and reactive oxygen species (ROS), aberrant endocrine signaling, and genetic factors (Bulun et al., 2019; Kapoor et al., 2021; Taylor et al., 2021; Donnez and Cacciottola, 2022; Vercellini et al. 2024). However, a very comprehensive understanding is needed to detect and investigate the physiological, cytological and immunological events, as well as biochemical factors like oxidative stress and inflammation, encountered in the pelvic microenvironment of endometriosis patients. In this issue of Human Reproduction Open, Chaggar et al. (2024) report high rates of deep endometriosis induced by hemoperitoneum. In our invited commentary, we review the role of blood, hemoglobin (Hb), and iron in endometriosis pathogenesis, looking to elucidate the possible link suggested in this article. [...]
- Affiliations
Citations
Donnez, J., & Dolmans, M.-M. (2024). Endometriosis: from iron and macrophages to exosomes. Is the sky clearing? Human reproduction open, 2024(3), hoae034 [1-5]. https://doi.org/10.1093/hropen/hoae034 (Original work published 2024)