Establishment of a New Radiological Prognostic Score in Patients with Osteosarcoma
(2024) Journal of Oncology Research and Therapy — Vol. 9, n° 3, p. 10230 [1-8] (2024)
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- Authors
Manon, Julie 
- Abstract
- INTRODUCTION: Osteosarcoma (OSS) is the most common primary malignant bone tumor. Treatment includes surgery and chemotherapy. Various prognostic factors have been identified, but the influence of tumor bone densification on chemotherapy response remains uncertain. OBJECTIVE: This study aims to determine the impact of tumor bone condensation in OSS on therapeutic response to establish a potential new prognostic score. METHODS: This retrospective single-center study involved 20 patients (adults and children) diagnosed with OSS between August 2006 and December 2018, treated at Cliniques Universitaires SaintLuc (Brussels, Belgium). A tumor bone densification score was established, and chemotherapy response was evaluated. Followup data were collected, and statistical analysis was conducted. RESULTS: The study included 20 patients (11 males, 9 females) with a median follow-up of 110 months (range 61-199 months). The femur was the most common tumor site (65%). At diagnosis, 95% had localized disease, and 45% were classified as good responders to chemotherapy (= 90% tissue necrosis). The 5-year overall survival was excellent, with a 5-year disease-free survival of 70% (± 10.2%). Patients with metastatic disease had poorer survival. Poor response to preoperative chemotherapy was the main independent poor prognostic factor associated with diseasefree survival. CONCLUSION: This study confirmed a good prognosis for OSS patients in the localized stage treated with surgery and perioperative chemotherapy. Patients with metastases and poor response to preoperative chemotherapy had poorer survival. However, the study does not validate tumor bone condensation as a prognostic tool. Further research into other prognostic factors, such as the tumor microenvironment, is suggested.
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Citations
Rosier, G., Manon, J., Mazzeo, F., & Schubert, T. (2024). Establishment of a New Radiological Prognostic Score in Patients with Osteosarcoma. Journal of Oncology Research and Therapy, 9(3), 10230 [1-8]. https://doi.org/10.29011/2574-710x.10230 (Original work published 2024)