Etude prospective du rendement des biopsies endoscopiques dans le diagnostic différentiel des ulcérations gastriques
(1990) Acta Endoscopica — Vol. 20, n° 5, p. 527-535 (1990)
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- (en) No prospective study has evaluated the proportion of biopsies unusable by the pathologist and of biopsies positive for cancer in a comparative series of benign and malignant ulcerations. In the present study, a constant number of biopsies (n = 10) has been sampled following a systematic program from large gastric ulcers (> 8 mm). They have been kept in separate bottles and analysed by the pathologist according to the sampling sequence. Among 65 ulcerations, 11.5 % of the biopsies are non interpretable by the pathologist, that is half the proportion obtained in retrospective series. With regards to the benign and to the malignant lesions, the percentage of non interpretable biopsies are 14 % and 5.7 % respectively. In the sequence of sampling, the non usable biopsies are randomly distributed although in benign ulcers, a non significant increase in unusable biopsies is observed after 5 biopsies. 67.5 % of the 210 biopsies from 21 invasive cancers are positive, a proportion superior to results from the literature (49-56 %). No particular distribution of positive biopsies in the order of sampling is observed. In order to obtain a high probability (p = 0.999) of biopsies positive for cancer, the number of biopsies is 6 for one positive biopsy, 8 for 2 and 11 for 3. We recommend that endoscopists obtain between 8 and 11 biopsies in gastric ulcerations.
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Mainguet, P., Hamichi, L., Debongnie, J. C., Jouret, A., Haot, J., & Robert, A. (1990). Etude prospective du rendement des biopsies endoscopiques dans le diagnostic différentiel des ulcérations gastriques. Acta Endoscopica, 20(5), 527-535. https://doi.org/10.1007/BF02966782 (Original work published 1990)