Oral taurine supplementation modulates ethanol-conditioned stimulus preference.
(1998) Alcohol (New York) — Vol. 16, n° 3, p. 201-206 (1998)
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- The present study investigated the possible modulatory action of oral taurine supplementation on the rewarding and aversive properties of low and high ethanol doses in male Wistar rats. A vinegar odor stimulus was daily paired with either ethanol (0.3 or 2.0 g/kg) or saline. In addition, half of the rats were supplemented orally with taurine (0.5 g/kg/day). After eight conditioning sessions, all rats were tested for their vinegar stimulus preference or aversion. In nontaurine-treated rats, 2.0 g/kg ethanol conditioning induced a significant aversion for the vinegar stimulus, while there was no preference after 0.3 g/kg ethanol conditioning. However, in taurine-supplemented rats, the 2.0 g/kg ethanol-induced aversion for the stimulus was decreased significantly, while the rats administered the lower ethanol doses, 0.3 g/kg, in combination with taurine supplementation, demonstrated a significant stimulus preference. Such results suggest that taurine modulates some of the aversive or rewarding effects of ethanol.
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Quertemont, E., Goffaux, V., Vlaminck, A. M., Wolf, C., & De Witte, P. (1998). Oral taurine supplementation modulates ethanol-conditioned stimulus preference. Alcohol (New York), 16(3), 201-206. https://doi.org/10.1016/S0741-8329(98)00002-0 (Original work published 1998)