Kolbe Anodic Decarboxylation as a Green Way To Access 2-Pyrrolidinones
(2020) Organic Letters — Vol. 22, n° 5, p. 1771-1775 (2020)
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- Authors
Lam, Kevin 
- Abstract
- Nootropic compounds are a group of pharmacologically active pyrrolidones. These molecules, which enhance cognition properties and possess a large prescription field, are particularly interesting synthetic targets for the pharmaceutical industry. In this Article, we disclose an effective and environmentally friendly pyrrolidinone synthesis using electrosynthesis. The newly developed methodology includes a Kolbe decarboxylation, followed by an intramolecular radical cyclization and a radical−radical cross-coupling.
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Citations
Quertenmont, M., Goodall, I., Lam, K., Markó, I. E., & Riant, O. (2020). Kolbe Anodic Decarboxylation as a Green Way To Access 2-Pyrrolidinones. Organic Letters, 22(5), 1771-1775. https://doi.org/10.1021/acs.orglett.0c00056 (Original work published 2020)