Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status.
(2011) Diabetologia : clinical and experimental diabetes and metabolism — Vol. 54, n° 12, p. 3101-3110 (2011)
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- Abstract
- The glucose-lowering drug metformin has been shown to activate hepatic AMP-activated protein kinase (AMPK), a master kinase regulating cellular energy homeostasis. However, the underlying mechanisms remain controversial and have never been investigated in primary human hepatocytes.
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Stéphenne, X., Foretz, M., Taleux, N., van der Zon, G. C., Sokal, E., Hue, L., Viollet, B., & Guigas, B. (2011). Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status. Diabetologia : clinical and experimental diabetes and metabolism, 54(12), 3101-3110. https://doi.org/10.1007/s00125-011-2311-5 (Original work published 2011)