Impairment of Rat Fetal Beta-Cell Development by Maternal Exposure to Dexamethasone during Different Time-Windows.

Dumortier, Olivier;Theys, Nicolas;Ahn, Marie-Thérèse;Remacle, Claude;Reusens, Brigitte
(2011) PLoS One — Vol. 6, n° 10, p. e25576 (2011)

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Authors
  • Dumortier, OlivierUCLouvain
    Author
  • Theys, NicolasUCLouvain
    Author
  • Ahn, Marie-ThérèseUCLouvain
    Collaborator
  • Remacle, ClaudeUCLouvain
    Author
  • Reusens, BrigitteUCLouvain
    Author
Abstract
Glucocorticoids (GCs) take part in the direct control of cell lineage during the late phase of pancreas development when endocrine and exocrine cell differentiation occurs. However, other tissues such as the vasculature exert a critical role before that phase. This study aims to investigate the consequences of overexposure to exogenous glucocorticoids during different time-windows of gestation for the development of the fetal endocrine pancreas.
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Dumortier, O., Theys, N., Remacle, C., & Reusens, B. (2011). Impairment of Rat Fetal Beta-Cell Development by Maternal Exposure to Dexamethasone during Different Time-Windows. PLoS One, 6(10), e25576. https://doi.org/10.1371/journal.pone.0025576 (Original work published 2011)