Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups.

Tan, Wenfeng;Sunahori, Katsue;Zhao, Jian;Deng, Yun;Lauwerys, Bernard;et.al.
(2011) Arthritis & Rheumatism — Vol. 63, n° 9, p. 2755-2763 (2011)

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Authors
  • Tan, Wenfeng
    Author
  • Sunahori, Katsue
    Author
  • Zhao, Jian
    Author
  • Deng, Yun
    Author
  • Lauwerys, BernardUCLouvain
    Author
  • et. al.
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Abstract
T cells from patients with systemic lupus erythematosus (SLE) express increased amounts of PP2Ac, which contributes to decreased production of interleukin-2 (IL-2). Because IL-2 is important in the regulation of several aspects of the immune response, it has been proposed that PP2Ac contributes to the expression of SLE. This study was designed to determine whether genetic variants of PPP2AC are linked to the expression of SLE and specific clinical manifestations and account for the increased expression of PP2Ac.
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Tan, W., Sunahori, K., Zhao, J., Deng, Y., Kaufman, K. M., Kelly, J. A., Lauwerys, B., & et al. (2011). Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups. Arthritis & Rheumatism, 63(9), 2755-2763. https://doi.org/10.1002/art.30452 (Original work published 2011)