Optimal Levetiracetam Dosing in Neurological ICU Patients With Augmented Renal Clearance.

Honoré, Patrick;Blackman, Sydney
(2024) Critical Care Medicine — Vol. 52, n° 8, p. e431-e432 (2024)

Files

HonorePCritCareMed2024.pdf
  • Open Access
  • Adobe PDF
  • 304.17 KB
Download

Details

Authors
Abstract
(en) Valdes et al concluded that their study, which examined the population pharmacokinetics of levetiracetam in a critically ill neurosurgical population, found that this population required higher doses to achieve target levels. The study also found that augmented renal clearance (ARC), a phenomenon characterized by creatinine clearance (CrCl) greater than 130 mL/min/1.73m2, is commonly described in critically ill patients, especially neurological ICU patients. A dose of at least 1000 mg of levetiracetam twice daily was required to lead to optimal results and reduced the odds of seizure by 68% compared with low-dose regimens (500 mg bid) [...]
Affiliations

Citations

  • APA
  • Chicago
  • FWB

Honoré, P., & Blackman, S. (2024). Optimal Levetiracetam Dosing in Neurological ICU Patients With Augmented Renal Clearance. Critical Care Medicine, 52(8), e431-e432. https://doi.org/10.1097/CCM.0000000000006288 (Original work published 2024)