Sperm impairments in adult vesper mice (Calomys laucha) caused byin uteroexposure to bisphenol A
(2013) Andrologia — Vol. 46, n° 9, p. 971-978 (2013)
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- This study aimed to evaluate the effects of in utero administration of bisphenol A (BPA) on semen parameters of vesper mice. Sixty female Calomys laucha were divided into six groups and received by gavage during gestation the following substances: Water (negative control), Olive Oil (vehicle control), Diethylstilbestrol (DES – positive control – 6.5 μg kg−1 bw) and BPA (40, 80 and 200 μg kg−1 bw). Male offspring were euthanised at 70 days of age, and sperm parameters were analysed. BPA reduced normal sperm morphology (water = 96.1 ± 0.65; BPA200 = 96.8 ± 2.3%), sperm membrane integrity (water = 88.8 ± 1,65; BPA200 = 70.6 ± 4,15%), sperm motility (water = 87.5 ± 1.71; BPA200 = 51.3 ±9.9%) and in vitro penetration rates (water = 55.0 ± 7.14; BPA200 = 7.47 ±2.96%), but it did not affect body weight, anogenital distance, sperm DNA integrity and acrosome integrity. In conclusion, in utero exposure to BPA caused a reduction in sperm parameters of adult C. laucha. Natural mating studies should be conducted to verify the effects of BPA on fertility of the animals.
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de Miranda Vasconcellos Vilela, J., Hartmann, A., Silva, E. F., Cardoso, T., Corcini, C. D., Varela-Junior, A. S., Martinez, P. E., & Colares, E. P. (2013). Sperm impairments in adult vesper mice (Calomys laucha) caused byin uteroexposure to bisphenol A. Andrologia, 46(9), 971-978. https://doi.org/10.1111/and.12182 (Original work published 2013)