Copper/palladium-catalyzed 1,4 reduction and asymmetric allylic alkylation of α,β-unsaturated ketones: Enantioselective dual catalysis

Nahra, Fady;Macé, Y.;Lambin, D.;Riant, Olivier
(2013) Angewandte Chemie (International Edition) — Vol. 52, n° 11, p. 3208-3212 (2013)

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Authors
  • Nahra, FadyUCLouvain
    Author
  • Macé, Y.autre
    Author
  • Lambin, D.autre
    Author
  • Riant, OlivierUCLouvain
    Author
Abstract
Cooperative efforts: The catalytic coupling of the two organometallic intermediates is possible through a Cu/Pd-based dual catalysis (see scheme; LG=leaving group), in which the CuI catalytic cycle generates catalytically the starting material for the Pd0 catalytic cycle. Although reagents are present in stoichiometric amounts in the reaction mixture and are able to trap both active species, the desired reaction proceeds as planned. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Nahra, F., Macé, Y., Lambin, D., & Riant, O. (2013). Copper/palladium-catalyzed 1,4 reduction and asymmetric allylic alkylation of α,β-unsaturated ketones: Enantioselective dual catalysis. Angewandte Chemie (International Edition), 52(11), 3208-3212. https://doi.org/10.1002/anie.201208612 (Original work published 2013)