Exploring the role of AMPK-ACC signalling and lipid metabolism in platelet functions and thrombus formation
(2018)
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- Abstract
- Platelets are central actors in haemostasis and thrombosis. Their stimulation by thrombin or collagen induces the phosphorylation and inhibition of the acetyl-CoA carboxylase (ACC). Since ACC is crucial for the synthesis of fatty acids, which are essential for platelet structure, signalling and metabolism, we hypothesized that this enzyme plays a role in platelet function. We showed that constitutive ACC activation increases thromboxane generation, leading to enhanced platelet reactivity and thrombus formation. Lipidomic analysis of intraplatelet content revealed an increase in arachidonic acid-containing phospholipids, which are major precursors of thromboxane. Interestingly, ACC is phosphorylated in high-risk coronary artery disease patients.
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Citations
Lepropre, S. (2018). Exploring the role of AMPK-ACC signalling and lipid metabolism in platelet functions and thrombus formation. https://hdl.handle.net/2078.5/62385